Type 2 Inflammatory Diseases
Eosinophil-Driven Diseases (EDDs) are Type 2 Inflammatory Diseases, that can take several forms. Elevated eosinophils play a crucial role in EDDs. Eosinophilic immune dysfunction is responsible for the recruitment and activation of eosinophils and can trigger these illnesses.
It is a systemic allergic response due to an overreactive immune response, causing asthmatic problems and other diseases. Immune system, lungs, gut/stomach and skin can be affected in different ways.
In further pages, we will discuss the following EDDs in more details:
- EoE (Eosinophilic Esophagitis)
- Nasal Polyps
- AERD (Aspirin Exacerbated Reflux Disease) or Samter´s Triad
- Cold Urticaria
The following video introduces Eosinophil-Driven Diseases EDD/type 2 inflammation and its association with asthma.
(Below you can read the text of the video in your language)
Text of video
Is it more than “Just Asthma”? Understanding the sources of underlying inflammation.
Imagine you are going to see the doctor.
You know your doctor well due to your asthma, but you notice that when your asthma gets worse, your eczema gets worse.
Maybe they’re connected?
You doctor insists otherwise, but what if you’re right?
Type 2 inflammation is when the immune system becomes overactive, developing breathing problems and other diseases
Many diseases, including but not limited to asthma and atopic eczema, can be considered type 2 inflammatory diseases.
Despite their connections to many different diseases, many people aren’t aware of type 2 inflammation…
This is best seen through how researchers have understood eosinophils, an immune cell involved in triggering type 2 inflammation.
Eosinophils were traditionally dismissed in medical science.
They were only relevant to specific diseases with few uses.
But new research has brought a paradigm shift challenging this assumption.
Researchers now understand that they have a wide range of jobs throughout the body.
They’re involved in lung disease, bowel disease, skin and immune diseases, and are important in developing immunity against diseases.
There is also growing research on type 2 inflammation disease treatments, by targeting immune cells which cause type 2 inflammation.
When scientists used targeted treatments to block type 2 inflammation for severe asthma, patients also found it helped to treat atopic eczema and nasal polyps.
All of this shows how multiple type 2 inflammation connects these diseases.
But, for a series of diseases defined by interconnectivity, people who live with type 2 inflammatory diseases often feel isolated by a medical experience of misunderstandings and misdiagnosis.
If we learn more about type 2 inflammation, we can improve the lives of people with inflammatory diseases.