CompEx

Isifuba

1. Ukusetyenziswa kweCompEx kwizigulana ze-eosinophilic ezine-asthma enzima, engalawulwayo kwi-benralizumab.  Bolton C, Harrison T, Lugogo N, Fuhlbrigge A, Hirsch I, Bengtsson T, Peterson S, Sidaway M, Garcia Gil E, Fagerås M, Da Silva CA. ERJ Vula iRes. 2024 Mar 18;10(2):01025-2023. doi: 10.1183/23120541.01025-2023. eCollection 2024 Mar. PMID: 38500798. Inqaku le-PMC lasimahla
2. Impembelelo yexesha kunye nejografi kwi-CompEx Asma: isiphelo esihlanganisiweyo sokwanda.  Jauhiainen A, Scheepers LEJM, Fuhlbrigge AL, Harrison T, Zangrilli J, Garcia Gil E, Gustafson P, Fagerås M, Da Silva CA. ERJ Vula iRes. 2020 Okt 19;6(4):00246-2020. doi: 10.1183/23120541.00246-2020. eCollection 2020 Okt. PMID: 33123561. Inqaku le-PMC lasimahla
3. Isiphelo senoveli sokunyuka kwe-asthma ukukhawulezisa uphuhliso lweklinikhi: uhlalutyo lwe-post-hoc lwezilingo ezilawulwa ngokungahleliwe.  Fuhlbrigge AL, Bengtsson T, Peterson S, Jauhiainen A, Eriksson G, Da Silva CA, Johnson A, Sethi T, Locantore N, Tal-Singer R, Fagerås M. Lancet Respir Med. 2017 Jul;5(7):577-590. doi: 10.1016/S2213-2600(17)30218-7. Epub 2017 Jun 2. PMID: 28583396 Ulingo lwezonyango.
4. Ukuthelekiswa kwenoveli ye-CompEx asthma exacerbation endpoint ukuya kwi-ATS / ERS ilungelelanise inkcazo ye-asthma emodareyithayo / ebukhali esetyenziswe kulingo lwe-MITRA.  Eriksson G, Nolte H, Ljørring C, Riis B, Virchow JC. Respir Med. 2019 Jul;153:1-2. doi: 10.1016/j.rmed.2019.04.014. Epub 2019 May 1. PMID: 31136926 
   Ulingo lwezonyango.
5. Uhlaziyo lweZiphumo ezixelwe ngesigulana kuMbefu.  Wu TD, Diamant Z, Hanania NA. Isifuba. 2024 May;165(5):1049-1057. doi: 10.1016/j.chest.2024.02.010. Epub 2024 Feb 15. PMID: 38365175
6. UWilkinson TMA, uAkuthota P. I-CompEx Asthma: ngaba lixesha lokutshintsha uvavanyo lweklinikhi?. Eur Respir J. 2025;66(3):2500470. Ipapashwe ngo-2025 nge-25 kaSeptemba. doi:10.1183/13993003.00470-2025
7. UCorren, uJonathan nabanye.I-FRONTIER-3: uphando lwesigaba sesi-2a olucwangcisiweyo ukuze kuphandwe i-tozorakimab, i-antibody ye-monoclonal anti-interleukin-33, kwi-asthma yokuqala." Uphando oluvulekileyo lwe-ERJ vol. 12,1 00183-2025. 23 Feb. 2026, doi:10.1183/23120541.00183-2025
8. UHung, uChun-Tse nabanye.Isibuko, isibuko eludongeni: ngaba iCompEx yeyona ndawo ilungileyo kunazo zonke?. " Uphando oluvulekileyo lwe-ERJ vol. 12,1 01258-2025. 23 Feb. 2026, doi:10.1183/23120541.01258-2025
9. UBolton, uClare nabanye.Ukubaluleka kweklinikhi kweCompEx Asthma kunye nempembelelo kwindlela yesifo: isiphumo seBenralizumab." Uphando oluvulekileyo lwe-ERJ vol. 12,1 00486-2025. 23 Feb. 2026, doi:10.1183/23120541.00486-2025
10. Mustapa, Mohd Nubli et al. “Isifundo seSigaba sesi-2a esilawulwa ngokungacwangciswanga, esingaboni kabini, esilawulwa yi-placebo ukuvavanya ukusebenza kakuhle kunye nokhuseleko lwe-londamocitinib (AZD4604) kabini ngosuku kangangeeveki ezili-12 kwizigulane ezindala ezine-asthma ephakathi ukuya kwenzima ezingalawulwayo kwi-ICS-LABA enedosi ephakathi nephezulu." Uphando lwe-BMJ oluvulelekileyo lokuphefumla Umqulu 13,1 e003589. 6 Matshi 2026, doi:10.1136/bmjresp-2025-003589

COPD

1. I-COPDCompEx: Isiphelo senoveli esiyintlanganisela yokwanda kweCOPD ukwenza uphuhliso lwezonyango olukhawulezayo.  Vogelmeier CF, Fuhlbrigge A, Jauhiainen A, Scheepers LEJM, Bengtsson T, Peterson S, Karlsson N, Sethi T, Locantore N, Tal-Singer R, Rennard S, Fagerås M, Da Silva CA. Respir Med. 2020 Nov;173:106175. doi: 10.1016/j.rmed.2020.106175. Epub 2020 Sep 28. PMID: 33032168
2. Iimvavanyo zoNyango kwiZigulana eziNcinci ezineSifo esiKhuselekileyo sePulmonary kunye neZigulana ze-Pre-Chronic Obstructive Pulmonary Disease: Ixesha lokuqhubela phambili.  Martinez FJ, Agusti A, Celli BR, Han MK, Allinson JP, Bhatt SP, Calverley P, Chotirmall SH, Chowdhury B, Darken P, Da Silva CA, Donaldson G, Dorinsky P, Dransfield M, Faner R, Halpin DM, Jones P, Krishnan JA, Locantore N, Martinerberova, Locantore N, Martinerberova H Price, Locantore N, Martinerberova C, Singh D, Vestbo J, Vogelmeier CF, Wise RA, Tal-Singer R, Wedzicha JA. NdinguJ Respir Crit Care Med. 2022 Feb 1;205(3):275-287. doi: 10.1164/rccm.202107-1663SO. PMID: 34672872. Inqaku le-PMC lasimahla
3. Intsingiselo yeklinikhi yeComposite Endpoint, i-COPDCompEx, ekuchazeni ubungozi kunye nokuwohloka kwe-COPD: Uhlalutyo lwePost Hoc lweZifundo ezi-4 zeKliniki eziPhakathi zeCOPD. UTal-Singer R, uVogelmeier CF, uBolton C, uBengtsson T, uPeterson S, uSidaway M, uDa Silva CA. Int J Chron Ukuthintela iPulmon Dis. 2026;21:603089
4. UHughes, uRod nabanye.Isigaba sesi-2a, Uvavanyo oluQhelekileyo lweMitiperstat xa kuthelekiswa nePlacebo kwizigulane ezineCOPD ezikuMngcipheko oPhezulu woKuba nzima (CRESCENDO)." Ijenali yamazwe ngamazwe yezifo ezingapheliyo zemiphunga Umqulu. 20 3305-3315. 24 Septemba 2025, doi:10.2147/COPD.S524775